SOX10 Antibody | V8947SAF-100UG

SOX10 Antibody | V8947SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: PCRP-SOX10-1D8

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: FACS, IF

Buffer: N/A

Limitation: This SOX10 antibody is available for research use only.

Purity: Protein A/G affinity

Description: This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. Expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Often used melanoma markers, such as anti-HMB45 and anti-MelanA, are poorly expressed in desmoplastic melanomas while SOX10 is moderately-to-strongly expressed in desmoplastic melanomas.

Immunogen: A portion of amino acids 90-179 was used as the immunogen for the SOX10 antibody.

Storage: Aliquot the SOX10 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.