SOCS3 Antibody | F53719-0.1ML

SOCS3 Antibody | F53719-0.1ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In ascites with 0.09% sodium azide

Format: Ascites

Clone: 532CT13.5.3

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: WB, ELISA

Buffer: N/A

Limitation: This SOCS3 antibody is available for research use only.

Purity: Ascites

Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity).

Immunogen: This SOCS3 antibody was produced from a mouse immunized with recombinant protein of human SOCS3.

Storage: Aliquot the SOCS3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.