SMAD7 Polyclonal Antibody | E-AB-65776

SMAD7 Polyclonal Antibody | E-AB-65776 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human

Host: Rabbit

Isotype: IgG

Application: WB, IF

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Background: The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.

Lead Time: 7~10 days

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant fusion protein of human SMAD7 (NP_005895.1).

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification: Affinity purification

Dilution: WB 1:500-1:1000 IF 1:50-1:100

Conjugation: Unconjugated

Calculated Molecular Weight: 23 kDa/46 kDa

Observed Molecular Weight: 46 kDa

Clonality: N/A