Description
SMAD6 Antibody | F49135-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: FACS, WB, ELISA
Buffer: N/A
Limitation: This SMAD6 antibody is available for research use only.
Purity: Antigen affinity
Description: SMAD6 acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions. [UniProt]
Immunogen: A portion of amino acids 358-386 from the human protein was used as the immunogen for this SMAD6 antibody.
Storage: Store at 4oC for up to one month. For long term, aliquot the SMAD6 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
