Description
SMAD4 Antibody | F50739-0.08ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human
Application: WB, IHC, IF, FACS, ELISA
Buffer: N/A
Limitation: This SMAD4 antibody is available for research use only.
Purity: Purified
Description: In muscle physiology, SMAD4 plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). [UniProt]
Immunogen: A portion of amino acids 400-428 from the human protein was used as the immunogen for this SMAD4 antibody.
Storage: Aliquot the SMAD4 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
