SMAD2 Antibody | F53216-0.4ML

SMAD2 Antibody | F53216-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Mouse

Application: WB, ELISA

Buffer: N/A

Limitation: This SMAD2 antibody is available for research use only.

Purity: Antigen affinity

Description: SMAD2 is a receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. [UniProt]

Immunogen: This SMAD2 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 106-140 amino acids from the N-terminal region of human SMAD2.

Storage: Aliquot the SMAD2 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.