Description
SLC5A5 - HEK293 Recombinant Cell line | 90333 | Gentaur US, UK & Europe Disrtribition
Category: Recombinant Cell Line/Ion Transporter
Application: • Drug compound screening, Functional assays
Background: Iodine transport is essential for the production of thyroid hormone (T4). Sodium Iodide Symporter SLC5A5 (NIS) is a sodium-dependent transporter of iodide into thyroid follicular cells and other peripheral tissues to support T4 synthesis [1]. Lack of iodide transport can result in hypothyroidism and can manifest itself in several disease states like goiter formation and weight gain. SLC5A5 also plays an important role in hyperthyroidism (an excessive production of T4). Expression and activity of SCL5A5 is altered in several forms of cancer. Inhibitors of SLC5A5 have potential therapeutic benefit for the regulation of iodine overload induced by amiodarone or other thyromimetics that can result in hyperthyroidism [2].
Description: Stable recombinant HEK293 cell line expressing human SLC5A5 (UniProt # Q92911) with a C-terminal FLAG- tag. SLC5A5 is a sodium-dependent iodide transporter and is a member of the sodium glucose co-transporter family. The expression of SLC5A5 is confirmed by Western blotting. This cell line can be used to evaluate agents that may affect iodide transport.
Product Type: Cell Line
Shippement Condition: -80°C (dry ice)
