Description
SIN1 Antibody | N1067-25UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 0.5 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat, Dog
Application: WB
Buffer: 1X PBS, pH 7.4
Limitation: This SIN1 antibody is available for research use only.
Purity: Protein A purified antibody
Description: mTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity.
Immunogen: A recombinant protein fragment from the C-terminal region of human SIN1 was used as the immunogen for this antibody.
Storage: Aliquot and store frozen at -20 °C or colder to avoid repeated freeze-thaw cycles.
