Description
SERPINB3 Antibody / SCCA-1 | V7494SAF-100UG | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free
Format: Purified
Clone: CPTC-SERPINB3-2
Host Animal: Mouse
Clonality: Monoclonal (mouse origin)
Species Reactivity: Human
Application: WB
Buffer: N/A
Limitation: This SERPINB3 antibody is available for research use only.
Purity: Protein G affinity chromatography
Description: Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of 'squamous cell carcinoma antigen', known as SCCA1 and SERPINB3, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1/SERPINB3 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation.
Immunogen: Recombinant human protein was used as the immunogen for this SERPINB3 antibody.
Storage: Store the SERPINB3 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).
