Semaphorin-4D Antibody / SEMA4D | V2452SAF-100UG

Semaphorin-4D Antibody / SEMA4D | V2452SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: A8

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human, Mouse

Application: Functional studies, FACS, IF

Buffer: N/A

Limitation: This Semaphorin-4D antibody is available for research use only.

Purity: Protein G affinity chromatography

Description: Recognizes a homodimeric protein comprised of 50kDa subunits, identified as Semaphorin-4D, or CD100. It is expressed on majority of haemopoietic cells (B, T, NK and myeloid cells) and is absent from bone marrow, erythrocytes, eosinophils and endothelial cells. Its expression is increased after PHA-activation. CD100 was shown to associate with different partner molecules in T cells such as CD45, a key molecule with protein tyrosine phosphatase activity involved in T-cell transduction, and a Serine kinase. It plays a role in homotypic cell adhesion and in T cell activation.

Immunogen: PHA stimulated human peripheral blood lymphocytes were used as the immunogen for the Semaphorin-4D antibody.

Storage: Store the Semaphorin-4D antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).