Description
Sclerostin Antibody / SOST | F54329-0.2ML | Gentaur US, UK & Europe Disrtribition
Family: Primary antibody
Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Species Reactivity: Human, Mouse, Rat
Application: IHC-P, WB
Buffer: N/A
Limitation: This Sclerostin antibody is available for research use only.
Purity: Antigen affinity purified
Description: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
Immunogen: A portion of amino acids 12-42 from the human protein was used as the immunogen for the Sclerostin antibody.
Storage: Aliquot the Sclerostin antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.
