Sclerostin Antibody / SOST | F54329-0.2ML

Sclerostin Antibody / SOST | F54329-0.2ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse, Rat

Application: IHC-P, WB

Buffer: N/A

Limitation: This Sclerostin antibody is available for research use only.

Purity: Antigen affinity purified

Description: Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Immunogen: A portion of amino acids 12-42 from the human protein was used as the immunogen for the Sclerostin antibody.

Storage: Aliquot the Sclerostin antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.