SARS-CoV-2 S1 protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H), Fc Tag | S1D-C5254-100ug

SARS-CoV-2 S1 protein (HV69-70del, Y144del, N501Y, A570D, D614G, P681H), Fc Tag | S1D-C5254-100ug| Gentaur Distribution US, UK & Europe

It's been reported that coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Source: SARS-CoV-2 S1 protein, Fc Tag (S1D-C5254) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Arg 685 (Accession # QHD43416.1). The mutations (HV69-70del, Y144del, N501Y, A570D, D614G, P681H) were identified in the SARS-CoV-2 Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01).

Format: Powder.

Tag: C-Fc.

Expression System: HEK293.

Expression Region: Val 16 - Arg 685.

Conjugate: Unconjugated.

Molecular Weight: 101.1 kDa.

Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 101.1 kDa. The protein migrates as 125-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 95%.

Buffer: 50 mM Tris, 100 mM Glycine, 0.2 M Arginine, 150 mM NaCl, pH7.5.

Storage Conditions: -20℃.

Shipping Conditions: RT