SARS-CoV-2 (COVID-19) S1 protein (N501Y), His Tag | S1N-C52Hg-1mg

SARS-CoV-2 (COVID-19) S1 protein (N501Y), His Tag | S1N-C52Hg-1mg| Gentaur Distribution US, UK & Europe

It's been reported that coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Source: SARS-CoV-2 S1 protein (N501Y), His Tag (S1N-C52Hg) is expressed from human 293 cells (HEK293). It contains AA Val 16 - Arg 685 (Accession # QHD43416.1 (N501Y) ). N501Y mutaion was identified in multiple SARS-CoV-2 Variants of Concerns (VOCs), i.e. the Alpha variant (Pango lineage: B.1.1.7; other names: 20I/501Y.V1 or VOC 202012/01), the Beta variant (Pango lineage: B.1.351; other names: 20H/501Y.V2), the Gamma variant (Pango lineage: P.1; other names: 20J/501Y.V3).

Format: Powder.

Tag: C-10×His.

Expression System: HEK293.

Expression Region: Val 16 - Arg 685.

Conjugate: Unconjugated.

Molecular Weight: 76.9 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 76.9 kDa. The protein migrates as 110-130 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Purity: 90%.

Buffer: PBS, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT