SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag | NS1-C51H7-1mg

SARS-CoV-2 (COVID-19) NSP1 Protein, His Tag | NS1-C51H7-1mg| Gentaur Distribution US, UK & Europe

The viral nonstructural protein 1 (nsP1) is the only membrane-associated protein that anchors the replication complex to the cellular membranes. NSP1 inhibits host translation by interacting with the 40S ribosomal subunit. The nsp1-40S ribosome complex further induces an endonucleolytic cleavage near the 5'UTR of host mRNAs, targeting them for degradation. Viral mRNAs are not susceptible to nsp1-mediated endonucleolytic RNA cleavage thanks to the presence of a 5'-end leader sequence and are therefore protected from degradation. By suppressing host gene expression, nsp1 facilitates efficient viral gene expression in infected cells and evasion from host immune response.

Source: SARS-CoV-2 NSP1, His Tag (NS1-C51H7) is expressed from E. coli cells. It contains AA Met 1 - Gly 180 (Accession # YP_009725297.1).

Format: Powder.

Tag: C-10×His.

Expression System: E. coli.

Expression Region: Met 1 - Gly 180.

Conjugate: Unconjugated.

Molecular Weight: 21.7 kDa.

Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.7 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE).

Purity: 90%.

Buffer: PBS, Arginine, pH7.4.

Storage Conditions: -20℃.

Shipping Conditions: RT