SAM68 Antibody / Src associated in mitosis 68 kDa protein | F53819-0.05ML

SAM68 Antibody / Src associated in mitosis 68 kDa protein | F53819-0.05ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human, Mouse

Application: WB, IHC-P

Buffer: N/A

Limitation: This SAM68 antibody is available for research use only.

Purity: Antigen affinity

Description: Src associated in mitosis 68 kDa protein is recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to.

Immunogen: A portion of amino acids 259-291 from the human protein was used as the immunogen for the SAM68 antibody.

Storage: Aliquot the SAM68 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.