S100A9 Antibody / MRP14 / Calgranulin B / Calprotectin L1H | V7141SAF-100UG

S100A9 Antibody / MRP14 / Calgranulin B / Calprotectin L1H | V7141SAF-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 1 mg/ml in 1X PBS; BSA free, sodium azide free

Format: Purified

Clone: PS1A9-1

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This S100A9 antibody is available for research use only.

Purity: PEG precipitation

Description: S100A9, also known as Calgranulin B or MRP14 (and Calprotectin L1H), is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. [UniProt]

Immunogen: Recombinant human protein was used as the immunogen for the S100A9 antibody.

Storage: Store the S100A9 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).