S100A9 Antibody / MRP14 / Calgranulin B / Calprotectin L1H | V2849-100UG

S100A9 Antibody / MRP14 / Calgranulin B / Calprotectin L1H | V2849-100UG | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide

Format: Purified

Clone: MRP14/840

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Species Reactivity: Human

Application: IHC-P

Buffer: N/A

Limitation: This MRP14 antibody is available for research use only.

Purity: PEG precipitation

Description: Recognizes a protein of14 kDa, identified as MRP-14 (also known as Calgranulin B, S100A9 and Calprotectin L1H). It comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. It is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore, it is also detectable in feces. Elevated levels have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions. This mAb reacts with neutrophils, monocytes, and macrophages, and has been shown as an important marker for identifying macrophages in tissue sections.

Immunogen: Recombinant human protein was used as the immunogen for the MRP14 antibody.

Storage: Store the MRP14 antibody at 2-8oC (with azide) or aliquot and store at -20 °C or colder (without azide).