Description
S- (+)-Rolipram | 27648-3 | Gentaur US, UK & Europe Disrtribition
Category: Phosphodiesterase/Inhibitors / Activators
Application: N/A
Background: Rolipram is a racemic drug that increases brain cAMP availability by inhibiting phosphodiesterase. The S-(+)-Rolipram enantiomer is 2-10x less potent than the R-(-)-Rolipram compound. PDE4B is involved in dopamine-associated and stress-related behaviours, and is believed to be the PDE4 subtype involved in the antipsychotic effects of PDE4 inhibitors such as rolipram.
Description: S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 µM. It has anti-inflammatory and anti-depressant activity in the central nervous system.
Product Type: Inhibitor
Shippement Condition: Room temp. (continental US) or gel packs
