S-adenosyl homocysteine | 52031

S-adenosyl homocysteine | 52031 | Gentaur US, UK & Europe Disrtribition

Category: Methyltransferase/Inhibitors / Activators

Application: Study enzyme kinetics, and screen small molecular inhibitors of S-adenosyl homocysteine hydrolase and histone methyltransferases for drug discovery and HTS applications.

Background: S-Adenosyl-L-homocysteine is an amino acid derivative used in several metabolic pathways in most organisms. S-Adenosyl-L-homocysteine (SAH) is an amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis. SAH is formed by the demethylation of S-adenosyl-L-methionine. It is also a product of S-adenosyl-methionine (SAM)-dependent methylation of biological molecules, including DNA, RNA, and histones and other proteins. Inhibitors that block its hydrolysis are being developed as anti-viral, anti-parasitic, anti-arthritic and immunosuppressive agents.

Description: S-(5'-Adenosyl)-L-homocysteine (AdoHCys, SAH) is a competitive inhibitor (versus AdoMet) of DNA methyltransferases. AdoHcy is used in a variety of studies on epigenetics in hyperhomocysteinemic states. EC Number: 213-560-8

Product Type: Reagent

Shippement Condition: -20°C