Description
RUNX1T1 Polyclonal Antibody | E-AB-67119 | Gentaur US, UK & Europe Disrtribition
Reactivity: Human
Host: Rabbit
Isotype: IgG
Application: WB
Research Area: Cancer, Epigenetics and Nuclear Signaling
Background: This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
Lead Time: 7~10 days
Concentration: 1 mg/mL
Storage: Store at -20°C. Avoid freeze / thaw cycles.
Immunogen: Recombinant fusion protein of human RUNX1T1 (NP_783554.1).
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification: Affinity purification
Dilution: WB 1:200-1:1000
Conjugation: Unconjugated
Calculated Molecular Weight: 44 kDa/48 kDa/63 kDa/64 kDa/67 kDa/68 kDa
Observed Molecular Weight: 67 kDa
Clonality: N/A
