RSPO3 Antibody / R-spondin 3 | F53890-0.2ML

RSPO3 Antibody / R-spondin 3 | F53890-0.2ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB

Buffer: N/A

Limitation: This RSPO3 antibody is available for research use only.

Purity: Antigen affinity

Description: R-spondin-3 is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Immunogen: A portion of amino acids 214-248 from the human protein was used as the immunogen for the RSPO3 antibody.

Storage: Aliquot the RSPO3 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.