ROS1 Antibody | F52830-0.4ML

ROS1 Antibody | F52830-0.4ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, ELISA

Buffer: N/A

Limitation: This ROS1 antibody is available for research use only.

Purity: Antigen affinity

Description: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Immunogen: This ROS1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1744-1777 amino acids from the C-terminal region of human ROS1.

Storage: Aliquot the ROS1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.