Description
ROR1, Fc-Fusion (IgG1), Avi-Tag | 79481-2 | Gentaur US, UK & Europe Disrtribition
Category: CAR-T/Protein
Application: N/A
Background: ROR1 is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors that play a role in the control of most basic cellular processes including cell proliferation, differentiation, migration and metabolism. Many human breast cancers express the ROR1 protein and high-level expression of ROR1 in breast adenocarcinoma is associated with aggressive disease. Silencing expression of ROR1 in human breast cancer cell lines found to express this protein impaired their growth in vitro and also in immune-deficient mice.
Description: Human ROR1, also known as receptor tyrosine kinase-like orphan receptor 1, neurotrophic tyrosine kinase, and receptor-related 1 (NTRKR1), GenBank Accession No. NM_005012, a.a 24-403, with C-terminal Avi-Tag™ fused to the Fc portion of Human IgG1 and expressed in a HEK293 cell expression system. MW = 71 kDa. This protein runs at a higher apparent M.W. by SDS-PAGE due to glycosylation.
Product Type: Protein
Shippement Condition: -80°C
