Description
ROCK2 Kinase Assay Kit | 78407 | Gentaur US, UK & Europe Disrtribition
Category: Kinase/Assay Kit
Application: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.
Background: ROCK2, an isoform of ROCK1, is a serine/threonine kinase target of small GTPase Rho that regulates the formation of actin stress fibers and focal adhesions, cytokinesis, and smooth muscle contraction. It is therefore important to proper vascular function and is involved in a number of fibrotic pathologies. The ROCK2 inhibitor Fasudil has been investigated for the treatment of cerebral cavernous malformation (CCM), which causes brain hemorrhages, and is in clinical trials for other applications such as Amyotrophic Lateral Sclerosis (ALS). Belumosudil, a newer ROCK2 inhibitor, was approved by the FDA for chronic graft versus host disease in 2021.
Description: The ROCK2 Kinase Assay Kit is designed to measure ROCK2 kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
Product Type: Assay Kit
Shippement Condition: -80°C
