Description
RIPK2, GST-tag | 40173 | Gentaur US, UK & Europe Disrtribition
Category: Kinase-Serine/Threonine/Protein
Application: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling
Background: RIPK2 (RIP2; RICK) is a death domain-containing protein kinase encoding a predicted 540-amino acid protein which contains an N-terminal serine/threonine kinase catalytic domain and a C-terminal caspase activation and recruitment domain. RIPK2 is thought to regulate apoptosis induced by the FAS receptor pathway (1). RIPK2 has been shown to specifically interact with the CARD of ICE/caspase-1 and this interaction correlates with the processing of pro-caspase-1 and the formation of the active caspase-1 p20 (2).
Description: Recombinant human RIPK2 (GenBank Accession No. NM_003821), (a.a. 1-299) with N-terminal Gst-tag, MW=59 kDa, expressed in an baculovirus infected Sf9 cell expression system.
Product Type: Protein
Shippement Condition: -80°C
