RIPK1 Antibody | F43338-0.08ML

RIPK1 Antibody | F43338-0.08ML | Gentaur US, UK & Europe Disrtribition

Family: Primary antibody

Formulation: In 1X PBS, pH 7.4, with 0.09% sodium azide

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Species Reactivity: Human

Application: WB, IHC, ELISA

Buffer: N/A

Limitation: This RIPK1 antibody is available for research use only.

Purity: Antigen affinity

Description: Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

Immunogen: A portion of amino acids 152-180 from the human protein was used as the immunogen for this RIPK1 antibody.

Storage: Aliquot the RIPK1 antibody and store frozen at -20 °C or colder. Avoid repeated freeze-thaw cycles.