Description
Rhesus macaque Growth Hormone R (GHR) Protein, Fc Tag | GHR-C5253-100ug| Gentaur Distribution US, UK & Europe
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Source: Rhesus macaque GHR, Fc Tag (GHR-C5253) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Tyr 264 (Accession # P79194-1).
Format: Powder.
Tag: C-Fc.
Expression System: HEK293.
Expression Region: Phe 19 - Tyr 264.
Conjugate: Unconjugated.
Molecular Weight: 54.7 kDa.
Characteristics: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 54.7 kDa. The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity: 90%.
Buffer: Tris with Glycine, Arginine and NaCl, pH7.5.
Storage Conditions: -20℃.
Shipping Conditions: RT
