Recombinant SF3B1 Monoclonal Antibody | E-AB-81510

Recombinant SF3B1 Monoclonal Antibody | E-AB-81510 | Gentaur US, UK & Europe Disrtribition

Reactivity: Human, Mouse, Hamster

Host: Rabbit

Isotype: IgG

Application: WB, IHC-P

Research Area: Cancer, Epigenetics and Nuclear Signaling

Background: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.

Lead Time: 7~10 days

Concentration: 300 μg/mL

Storage: Store at -20℃. Avoid freeze / thaw cycles.

Immunogen: N/A

Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Purification: Affinity Purified

Dilution: WB 1:500-1:1000 IHC 1:50-1:100

Conjugation: Unconjugated

Calculated Molecular Weight: 146kDa

Observed Molecular Weight: 146kDa

Clonality: Rabbit Monoclonal