Recombinant Rhesus macaque HVEM/TNFRSF14/CD270 Protein (His Tag) | PKSQ050069

Recombinant Rhesus macaque HVEM/TNFRSF14/CD270 Protein (His Tag) | PKSQ050069 | Gentaur US, UK & Europe Disrtribition

Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM

Active Protein: N/A

Activity: Recombinant Rhesus macaque HVEM is produced by our Mammalian expression system and the target gene encoding Leu39-Val203 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Rhesus macaque HVEM is produced by our Mammalian expression system and the target gene encoding Leu39-Val203 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-His

Species: Rhesus macaque

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 18.3 kDa

Formulation: Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Reconstitution: Not Applicable

Background: Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

Research Area: N/A