Recombinant Rat TNF-αsf protein(His tag) | PKSR500005

Recombinant Rat TNF-αsf protein(His tag) | PKSR500005 | Gentaur US, UK & Europe Disrtribition

Synonyms: Cachectin;TNF-alpha;Tumor necrosis factor ligand superfamily member 2;TNF-a;N-terminal fragment;NTF;ICD1;ICD2

Active Protein: N/A

Activity: A DNA sequence encoding theRat TNF-αsf protein (P16599) (Gly57-Leu235) was expressed with a N-His.

Protein Construction: A DNA sequence encoding theRat TNF-αsf protein (P16599) (Gly57-Leu235) was expressed with a N-His.

Fusion Tag: N-His

Species: Rat

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 19.7 kDa

Formulation: Lyophilized from sterile PBS, pH 7.5, 5% trehalose, 5% mannitol, 0.01% tween-80.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance.Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6.

Research Area: N/A