Description
Recombinant Rat SCF/c-Kit Ligand Protein (Human Cells, His Tag) | PKSR030459 | Gentaur US, UK & Europe Disrtribition
Synonyms: FPH2; KIT ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; MGFSHEP7; SCF; SFc-Kit ligand; SLF; steel factor; Stem Cell Factor; c-kit Ligand
Active Protein: N/A
Activity: Recombinant Rat SCF is produced by our Mammalian expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus.
Protein Construction: Recombinant Rat SCF is produced by our Mammalian expression system and the target gene encoding Gln26-Ala189 is expressed with a 6His tag at the C-terminus.
Fusion Tag: C-His
Species: Rat
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 19.4 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution: Please refer to the printed manual for detailed information.
Background: SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two- to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.
Research Area: N/A
