Recombinant Rat PDGF-B Protein (His Tag) | PKSR040476

Recombinant Rat PDGF-B Protein (His Tag) | PKSR040476 | Gentaur US, UK & Europe Disrtribition

Synonyms: Becaplermin;PDGF 2;PDGF B chain;PDGF subunit B;PDGF-2;PDGF2;Pdgfb;PDGFB;Platelet derived growth factor 2;Platelet-derived growth factor B chain;Platelet-derived growth factor beta polypeptide;Platelet-derived growth factor subunit B;Proto-oncogene c-Sis;SIS;SSV

Active Protein: N/A

Activity: A DNA sequence encoding the Rat PDGF-B (Q05028-1) (Ser74-Thr182) was expressed with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the Rat PDGF-B (Q05028-1) (Ser74-Thr182) was expressed with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Rat

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 12.2 kDa

Formulation: Supplied as sterile 20mM Tris, 1mM EDTA, 25% glycerol, pH8.0

Reconstitution: Not Applicable

Background: The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Research Area: N/A