Recombinant Rat Interleukin-2/IL-2 Protein (His Tag) | PKSR030460

Recombinant Rat Interleukin-2/IL-2 Protein (His Tag) | PKSR030460 | Gentaur US, UK & Europe Disrtribition

Synonyms: Interleukin-2; IL-2; T-cell growth factor; TCGF; Aldesleukin; IL2

Active Protein: N/A

Activity: Recombinant Rat Interleukin-2 is produced by our Mammalian expression system and the target gene encoding Ala21-Gln155 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Rat Interleukin-2 is produced by our Mammalian expression system and the target gene encoding Ala21-Gln155 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-His

Species: Rat

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 16.3 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 5mM NaH2PO4, 5mM Citric acid, 150mM NaCl, pH4.0.

Reconstitution: Not Applicable

Background: Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2, respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.

Research Area: N/A