Recombinant Rat IL-6 Protein | PKSR500002

Recombinant Rat IL-6 Protein | PKSR500002 | Gentaur US, UK & Europe Disrtribition

Synonyms: Interleukin-6, IL6, Il-6

Active Protein: N/A

Activity: A DNA sequence encoding the Rat IL-6 protein (P20607) (1-211) was expressed with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the Rat IL-6 protein (P20607) (1-211) was expressed with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Rat

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 24 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol, 0.01% tween-80.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.

Research Area: Cancer, Cardiovascular, Immunology, Cytokines