Recombinant Rat IL-6/Interleukin-6 Protein (Active) | PKSR030420

Recombinant Rat IL-6/Interleukin-6 Protein (Active) | PKSR030420 | Gentaur US, UK & Europe Disrtribition

Synonyms: IL6

Active Protein: Active protein

Activity: A DNA sequence encoding the rat IL6 (Phe25-Thr211) was expressed and purified with an initial Met.

Protein Construction: A DNA sequence encoding the rat IL6 (Phe25-Thr211) was expressed and purified with an initial Met.

Fusion Tag: N/A

Species: Rat

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 21.9 kDa

Formulation: Lyophilized from sterile 40% acetonitrile, 0.1% TFA

Reconstitution: Please refer to the printed manual for detailed information.

Background: Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as phosphorylated and variably glycosylated molecule. It exerts actions through the its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined an essential role in directing transition from innate to acquired immunity.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Research Area: N/A