Recombinant Rat CLEC5A/MDL1/MDL-1 Protein (His Tag) | PKSR030283

Recombinant Rat CLEC5A/MDL1/MDL-1 Protein (His Tag) | PKSR030283 | Gentaur US, UK & Europe Disrtribition

Synonyms: CLEC5A

Active Protein: N/A

Activity: A DNA sequence encoding the rat CLEC5A (F7GAV1) (Val30-Lys190) was expressed with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the rat CLEC5A (F7GAV1) (Val30-Lys190) was expressed with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Rat

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 20.6 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: CLEC5A, also known as MDL1 and MDL-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC5A with dnax-activation protein 12 and may play a role in cell activation. It also functions as a positive regulator of osteoclastogenesis. CLEC5A acts as a key regulator of synovial injury and bone erosion during autoimmune joint inflammation .The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release.

Research Area: N/A