Recombinant Rat AMPK alpha2 Protein (His Tag) | PKSR040467

Recombinant Rat AMPK alpha2 Protein (His Tag) | PKSR040467 | Gentaur US, UK & Europe Disrtribition

Synonyms: 5'-AMP-activated protein kinase catalytic subunit alpha-2;AAPK2;ACACA kinase;Acetyl-CoA carboxylase kinase;AMPK alpha 2 chain;AMPK subunit alpha-2;AMPK2;AMPKa2;AMPKalpha2;HMGCR kinase;Hydroxymethylglutaryl-CoA reductase kinase;PRKAA;PRKAA2;Protein kinase AMP activated alpha 2 catalytic subunit;Protein kinase AMP activated catalytic subunit alpha 2

Active Protein: N/A

Activity: A DNA sequence encoding the Rat AMPK alpha2 (Q09137-1) (Tyr16-Val195) was expressed with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the Rat AMPK alpha2 (Q09137-1) (Tyr16-Val195) was expressed with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Rat

Expressed Host: E.coli

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 20 kDa

Formulation: Supplied as sterile 20mM Tris, 1mM EDTA, 25% glycerol, pH8.0

Reconstitution: Not Applicable

Background: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

Research Area: N/A