Recombinant Mouse Thrombomodulin/THBD Protein (His Tag) | PKSM041274

Recombinant Mouse Thrombomodulin/THBD Protein (His Tag) | PKSM041274 | Gentaur US, UK & Europe Disrtribition

Synonyms: Thrombomodulin; TM; Fetomodulin; CD141; BDCA-3; Thbd

Active Protein: N/A

Activity: Recombinant Mouse Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Leu17-Ser517 is expressed with a 6His tag at the C-terminus.

Protein Construction: Recombinant Mouse Thrombomodulin is produced by our Mammalian expression system and the target gene encoding Leu17-Ser517 is expressed with a 6His tag at the C-terminus.

Fusion Tag: C-His

Species: Mouse

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 54.6 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH8.0.

Reconstitution: Not Applicable

Background: Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a mature chain (aa 17 to 577) that consists of the following domains: C-type lectin, EGF-like, transmembrane and cytoplasmic. Mouse THBD is corresponding to the extracellular portion of the type I membrane protein. Predominantly synthesized by vascular endothelial cells, THBD inhibits coagulation and fibrinolysis. It functions as a cell surface receptor and an essential cofactor for active thrombin, which in turn activates protein C and thrombinactivatable fibrinolysis inhibitor (TAFI), also known as carboxypeptidase B2 (CPB2). In addition, THBD gene polymorphisims are associated with human disease and THBD plays a role in thrombosis, stroke, arteriosclerosis, and cancer.

Research Area: N/A