Recombinant Mouse SerpinE2/SERPINE2 Protein (His Tag) | PKSM041335

Recombinant Mouse SerpinE2/SERPINE2 Protein (His Tag) | PKSM041335 | Gentaur US, UK & Europe Disrtribition

Synonyms: Glia-derived nexin; GDN; Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serine protease-inhibitor 4; Serpin E2; Pi7; Pn1; Spi4

Active Protein: N/A

Activity: Recombinant Mouse Serpin E2 is produced by our Mammalian expression system and the target gene encoding Ser20-Pro397 is expressed with a 10His tag at the C-terminus.

Protein Construction: Recombinant Mouse Serpin E2 is produced by our Mammalian expression system and the target gene encoding Ser20-Pro397 is expressed with a 10His tag at the C-terminus.

Fusion Tag: C-His

Species: Mouse

Expressed Host: Human Cells

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at<-20°C.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Molecular Mass: 43.2 kDa

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 150 mM NaCl, pH8.0.

Reconstitution: Not Applicable

Background: Serpin E2 is a member of the Serpin superfamily of the serine protease inhibitors. Serpin E2 is apotent inhibitor of thrombin, plasmin and plasminogen activators. It is differentially expressed during neuronal differentiation and is able to transform humanembryonic kidney cells into neuronlikecells. Its over-expressionin mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressedin the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronicpancreatitis tissue samples. It plays an important role in controlling male fertility because its knockout male mice show a marked impairment in fertility from theonset of sexual maturity and its abnormal expression is found in the semen of men with seminal dysfunction.

Research Area: N/A