Recombinant Mouse Reticulocalbin 3/RCN3 Protein (His Tag) | PKSM040309

Recombinant Mouse Reticulocalbin 3/RCN3 Protein (His Tag) | PKSM040309 | Gentaur US, UK & Europe Disrtribition

Synonyms: 6030455P07Rik;D530026G20Rik;D7Ertd671e;RLP49

Active Protein: N/A

Activity: A DNA sequence encoding the mouse Rcn3 (NP_080831.2) (Met1-Leu328) was expressed with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the mouse Rcn3 (NP_080831.2) (Met1-Leu328) was expressed with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Mouse

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 36.9 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: RCN3 belongs to the CREC family which contains multiple EF-hand Ca2+-binding proteins localized to the secretory pathway. RCN3 sequence is characterized by the presence of five Arg-Xaa-Xaa-Arg motifs, which represents the target sequence of subtilisin-like proprotein convertases(SPCs). SPCs are a family of seven structurally related serine endoproteases that are involved in the proteolytic activation of proproteins.RCN3 is transiently associated with proPACE4, but not with mature PACE4. Inhibition of PACE4 maturation by a Ca2+ ionophore resulted in accumulation of the proPACE4-RCN-3 complex in cells. It has been proposed that elective and transient association of RCN3 with the precursor of PACE4 plays an important role in the biosynthesis of PACE4.

Research Area: N/A