Recombinant Mouse PTPN6/SH-PTP1 Protein (aa 207-597, His & GST Tag)(Active) | PKSM040450

Recombinant Mouse PTPN6/SH-PTP1 Protein (aa 207-597, His & GST Tag)(Active) | PKSM040450 | Gentaur US, UK & Europe Disrtribition

Synonyms: 70Z-SHP;hcp;Hcph;me;Ptp1C;PTPTY-42;SH-PTP1;SHP-1

Active Protein: Active protein

Activity: A DNA sequence encoding the mouse PTPN6 (P29351-2) (Ala207-Lys597) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Protein Construction: A DNA sequence encoding the mouse PTPN6 (P29351-2) (Ala207-Lys597) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.

Fusion Tag: N-His-GST

Species: Mouse

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 85 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 72.7 kDa

Formulation: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.0, 10% glycerol

Reconstitution: Please refer to the printed manual for detailed information.

Background: PTPN6 is an enzyme which belongs to the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of PTPN6 contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of PTPN6 with its substrates. PTPN6 is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. It has been shown that PTPN6 interacts with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.

Research Area: N/A