Recombinant Mouse PTPN2/PTPT Protein (aa 2-314, His Tag)(Active) | PKSM040482

Recombinant Mouse PTPN2/PTPT Protein (aa 2-314, His Tag)(Active) | PKSM040482 | Gentaur US, UK & Europe Disrtribition

Synonyms: AI325124;Ptpt;TC-PTP

Active Protein: Active protein

Activity: A DNA sequence encoding the mouse PTPN2 (Q06180-1) (Ser 2-Asn 314) was fused with a polyhistidine tag at the N-terminus.

Protein Construction: A DNA sequence encoding the mouse PTPN2 (Q06180-1) (Ser 2-Asn 314) was fused with a polyhistidine tag at the N-terminus.

Fusion Tag: N-His

Species: Mouse

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 38.7 kDa

Formulation: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 20% gly, 0.1mM TCEP

Reconstitution: Please refer to the printed manual for detailed information.

Background: Tyrosine-protein phosphatase non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2 and PTPT, is a cytoplasm protein which belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif, which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.

Research Area: N/A