Description
Recombinant Mouse NCR1 Protein (His Tag) | PKSM041113 | Gentaur US, UK & Europe Disrtribition
Synonyms: Activating receptor1; mAR-1; Lymphocyte antigen94; Naturalkiller cell p46-related protein; NK-p46; NKp46; mNKp46
Active Protein: N/A
Activity: Recombinant Mouse Natural cytotoxicity triggering receptor 1 is produced by our Mammalian expression system and the target gene encoding Glu22-Asn255 is expressed with a Fc tag at the C-terminus.
Protein Construction: Recombinant Mouse Natural cytotoxicity triggering receptor 1 is produced by our Mammalian expression system and the target gene encoding Glu22-Asn255 is expressed with a Fc tag at the C-terminus.
Fusion Tag: C-6His
Species: Mouse
Expressed Host: Human Cells
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 95 % as determined by reducing SDS-PAGE.
Endotoxin: < 1.0 EU per μg as determined by the LAL method.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 53.5 kDa
Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .
Reconstitution: Please refer to the printed manual for detailed information.
Background: Natural cytotoxicity triggering receptor 1(NKp46/NCR1) is a single-pass type I membrane protein. It consists of two extracellular Ig-like domains followed by a short stalk region, a transmembrane domain containing a positively charged amino acid residue, and a short cytoplasmictail. NKp46 is predominantly expressed in the embryo. It has a positive charge in its transmembrane domain that permits association with the ITAM-bearing signal adapter proteins, CD3 zeta and Fc epsilon RI gamma. These receptors are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. Studies with neutralizing antibodies indicate that the three NCR are primarily responsible for triggering the NK-mediated lysis of many human tumor celllines.
Research Area: N/A
