Description
Recombinant Mouse MOG Protein (aa30-149, His Tag) | PKSM040378 | Gentaur US, UK & Europe Disrtribition
Synonyms: B230317G11Rik
Active Protein: N/A
Activity: A DNA sequence encoding the mouse MOG (Q61885) extracellular domain (Gly 29-Thr 156) was expressed, with a C-terminal polyhistidine tag.
Protein Construction: A DNA sequence encoding the mouse MOG (Q61885) extracellular domain (Gly 29-Thr 156) was expressed, with a C-terminal polyhistidine tag.
Fusion Tag: C-His
Species: Mouse
Expressed Host: E.coli
Shipping: This product is provided as lyophilized powder which is shipped with ice packs.
Purity: > 97 % as determined by reducing SDS-PAGE.
Endotoxin: Please contact us for more information.
Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Molecular Mass: 16 kDa
Formulation: Lyophilized from sterile PBS, pH 5.4, 5% Trehalose, 5% Mannitol, 0.01 % Tween-80
Reconstitution: Please refer to the printed manual for detailed information.
Background: Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.
Research Area: N/A
