Recombinant Mouse KYNU/Kynureninase Protein (His Tag)(Active) | PKSM040748

Recombinant Mouse KYNU/Kynureninase Protein (His Tag)(Active) | PKSM040748 | Gentaur US, UK & Europe Disrtribition

Synonyms: 4432411A05Rik

Active Protein: Active protein

Activity: A DNA sequence encoding the mouse KYNU (Q9CXF0) (Met 1-Ser 464) was expressed，with a C-terminal polyhistidine tag.

Protein Construction: A DNA sequence encoding the mouse KYNU (Q9CXF0) (Met 1-Ser 464) was expressed，with a C-terminal polyhistidine tag.

Fusion Tag: C-His

Species: Mouse

Expressed Host: Baculovirus-Insect Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 94 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 53.7 kDa

Formulation: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0

Reconstitution: Please refer to the printed manual for detailed information.

Background: Genetic studies in mouse and human suggest that kynureninase activity may influence blood pressure and renal function. The gene coding kynureninase (KYNU) is also located on chromosome band 2q14-q23, where a linkage peak for essential hypertension was previously detected in the Chinese Han population.The results show that the rare KYNU variant Arg188Gln affects kynureninase activity and are consistent with the hypothesis that this mutation can predispose to essential hypertension.

Research Area: N/A