Recombinant Mouse JAM-A/F11R Protein (Fc Tag) | PKSM040670

Recombinant Mouse JAM-A/F11R Protein (Fc Tag) | PKSM040670 | Gentaur US, UK & Europe Disrtribition

Synonyms: 9130004G24;AA638916;ESTM33;JAM;JAM-1;JAM-A;Jcam;Jcam1;Ly106

Active Protein: N/A

Activity: A DNA sequence encoding the mouse F11R (NP_766235.1) extracellular domain (Met 1-Ala 242) was fused with the Fc region of human IgG1 at the C-terminus.

Protein Construction: A DNA sequence encoding the mouse F11R (NP_766235.1) extracellular domain (Met 1-Ala 242) was fused with the Fc region of human IgG1 at the C-terminus.

Fusion Tag: C-Fc

Species: Mouse

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 94 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 50.2 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Junctional adhesion molecule-A (JAM-A), also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321), is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells, as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses). It is also a ligand for the integrin LFA1, involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily, JAM-A protein involves in platelet adhesion, secretion and aggregation, and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition, it may be a potential therapeutic target for breast cancer.

Research Area: N/A