Recombinant Mouse HPGD/15-PGDH Protein (His Tag)(Active) | PKSM040631

Recombinant Mouse HPGD/15-PGDH Protein (His Tag)(Active) | PKSM040631 | Gentaur US, UK & Europe Disrtribition

Synonyms: 15-PGDH;AV026552

Active Protein: Active protein

Activity: A DNA sequence encoding the mouse HPGD (Q8VCC1) (Met 1-Ser 269) was expressed, with a polyhistide tag at the C-terusmin.

Protein Construction: A DNA sequence encoding the mouse HPGD (Q8VCC1) (Met 1-Ser 269) was expressed, with a polyhistide tag at the C-terusmin.

Fusion Tag: C-His

Species: Mouse

Expressed Host: E.coli

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: Please contact us for more information.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 30.6 kDa

Formulation: Lyophilized from sterile PBS, pH 8.0, 20% glycerol

Reconstitution: Please refer to the printed manual for detailed information.

Background: 15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor in many species and regulate uterine contractility and cervical dilatation. Therefore, the regulation of prostaglandin output by PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activity patterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) , cranioosteoarthropathy (COA),  and isolated congenital nail clubbing.

Research Area: N/A