Recombinant Mouse GITR/TNFRSF18 Protein (Fc & His Tag)(Active) | PKSM041029

Recombinant Mouse GITR/TNFRSF18 Protein (Fc & His Tag)(Active) | PKSM041029 | Gentaur US, UK & Europe Disrtribition

Synonyms: Tumor necrosis factor receptor superfamily member 18;Glucocorticoid-induced TNFR-related protein;Tnfrsf18; AITR;CD357;GITR-D;TNFRSF18

Active Protein: Active protein

Activity: Recombinant Mouse Glucocorticoid Induced TNF Receptor Family Related Gene is produced by our Mammalian expression system and the target gene encoding Ser22-His153 is expressed with a Fc, 6His tag at the C-terminus.

Protein Construction: Recombinant Mouse Glucocorticoid Induced TNF Receptor Family Related Gene is produced by our Mammalian expression system and the target gene encoding Ser22-His153 is expressed with a Fc, 6His tag at the C-terminus.

Fusion Tag: C-Fc-6His

Species: Mouse

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 41.12 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Research Area: N/A