Recombinant Mouse EpCAM/TROP-1 Protein (His Tag) | PKSM040591

Recombinant Mouse EpCAM/TROP-1 Protein (His Tag) | PKSM040591 | Gentaur US, UK & Europe Disrtribition

Synonyms: Neurotrophic tyrosine kinase receptor-related 1; receptor tyrosine kinase-like orphan receptor 1; ROR1;tyrosine-protein kinase transmembrane receptor ROR1; Epithelial cell adhesion molecule; Tumor-associated calcium signal transducer 1;TROP1;CD326;EGP;EGP-2;Egp314;Ep-CAM;EpCAM1;GA733-2;gp40;Ly74;Tacsd1;Tacstd1

Active Protein: N/A

Activity: A DNA sequence encoding the extracellular domain of mouse EpCAM (NP_032558.2) (Met 1-Thr 266) was expressed, with a polyhistidine tag at the C-terminus.

Protein Construction: A DNA sequence encoding the extracellular domain of mouse EpCAM (NP_032558.2) (Met 1-Thr 266) was expressed, with a polyhistidine tag at the C-terminus.

Fusion Tag: C-His

Species: Mouse

Expressed Host: HEK293 Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 29 kDa

Formulation: Lyophilized from sterile PBS, pH 7.4

Reconstitution: Please refer to the printed manual for detailed information.

Background: Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Research Area: N/A