Recombinant Mouse EpCAM/TROP-1 Protein (Fc Tag)(Active) | PKSM041339

Recombinant Mouse EpCAM/TROP-1 Protein (Fc Tag)(Active) | PKSM041339 | Gentaur US, UK & Europe Disrtribition

Synonyms: Neurotrophic tyrosine kinase receptor-related 1; receptor tyrosine kinase-like orphan receptor 1; ROR1;tyrosine-protein kinase transmembrane receptor ROR1; Epithelial cell adhesion molecule; Tumor-associated calcium signal transducer 1;TROP1;CD326;EGP;EGP-2;Egp314;Ep-CAM;EpCAM1;GA733-2;gp40;Ly74;Tacsd1;Tacstd1

Active Protein: Active protein

Activity: Recombinant Mouse EpCAM is produced by our Mammalian expression system and the target gene encoding Gln24-Thr266 is expressed with a Fc tag at the C-terminus.

Protein Construction: Recombinant Mouse EpCAM is produced by our Mammalian expression system and the target gene encoding Gln24-Thr266 is expressed with a Fc tag at the C-terminus.

Fusion Tag: C-Fc

Species: Mouse

Expressed Host: Human Cells

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Purity: > 95 % as determined by reducing SDS-PAGE.

Endotoxin: < 1.0 EU per μg as determined by the LAL method.

Stability and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Molecular Mass: 54.8 kDa

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Reconstitution: Please refer to the printed manual for detailed information.

Background: ROR1，also known as Neurotrophic tyrosine kinase, receptor-related 1, belongs to the ROR subfamily of Tyr protein kinase family, a protein kinase superfamily. It has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. Human ROR1 shares 97% and 58% aa sequence identity with mouse ROR1 and human ROR2, respectively. ROR1 may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. Its Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Research Area: N/A